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Neurotechnology innovation for modular active high-density implantable CMOS-probes

Simultaneous Neural recording
Active Pixel Sensor technology

About Sinaps

We are grateful for the support of the Brain Initiative NIH funding in the project “Novel optrodes for large-scale electrophysiology and site-specific stimualtion” (U01NS094190-1) and to our project partners at IIT and Harvard University.

For the development of ChroMOS probes, we are also grateful to the European Commission for the support through the Marie Skłodowska-Curie Actions in the project “Toward monolithic CMOS based neural probes for stable chronic recording and brain machine interfaces” (ChroMOS project, H2020-MSCA-IF-2019, GA 896996).

About

The SiNAPS Concept

Advantages

  • Modular circuit architecture

    rapid design of probes with different layouts (single-/multi-shaft)

  • Versatile fabrication flow

    low-cost prototyping of CMOS-probes

  • Compact and scalable devices

    front-end circuits in-pixel avoid needs of large probe bases and allow >80 channels/mm2 of total device area.

Modular circuit architecture

different CMOS-probe layouts for in vivo electrophysiology

Active electrode-pixel

amplifiers and filters underneath each electrode

Sub-millisecond read-out circuits

On-probe addressing and time-division multiplexing circuits for whole array read-outs of thousands of electrodes at 25 ksample/s
Concept

Technical Specifications

One architecture, multiple layouts
Single Shank
Amplifier
In-pixel (DC-input)
Eletrode Size
20 x 20 µm²
Eletrode Pitch
28 µm
Sampling Frequency
up to 25 kHz/channel
Shank (L•W•T)
6.5 • 10³ x 120 x 30 µm³
Base (L•W)
1.7 x 1.12 mm²
Number of shanks
1
Shank’ Separation
NA
Electrode/Channels
512/512
RMS noise
7.5 µV
Power Consumption
<6 µW/electrode-pixel
Electrode Material
Pt/Au
Multi Shank
Amplifier
In-pixel (DC-input)
Eletrode Size
15 x 15 µm²
Eletrode Pitch
28 µm
Sampling Frequency
up to 25 kHz/channel
Shank (L•W•T)
5 • 10³ x 80 x 30 µm³
Base (L•W)
3.5 x 3 mm²
Number of shanks
4
Shank’ Separation
560 µm
Electrode/Channels
1024/1024
RMS noise
6.5 µV
Power Consumption
<6 µW/electrode-pixel
Electrode Material
Pt/Au
ChroMOS
Amplifier
In-pixel (DC-input)
Eletrode Size
ø 10 µm
Eletrode Pitch
29.5 µm inside module and 90 µm between modules (modules of 8 electrodes)
Sampling Frequency
up to 25 kHz/channel
Shank (L•W•T)
4 x 10³ x 26 x 20 µm³
Base (L•W)

1 x 2 mm2

Number of shanks

1

Shank’ Separation
N/A
Electrode/Channels
64/64
RMS noise
6.5 µV
Power Consumption
<6 µW/electrode-pixel
Electrode Material
Pt/Au
Compact and lightweight acquisition system from acute neural recordings.

Recorded Data

Example of in vivo full-band neural recordings collected from SiNAPS single and multi-shank probes implanted in rodents' brain. The raw neural traces are filtered in the LFP (1-300 Hz) and AP (300-5000 Hz) frequency bands and spiking activity is subsequently isolated and extracted.
Thanks to A.Sirota (LMU) and A.Jackson (Newcastle University) for pilot experiments.

Contact

To get in touch with the SiNAPS team just fill in this form and soemone from the team will get back to you.